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Pilot Awardees

Pilot awards were offered from 2011 to 2017, and were awarded to the following investigators with highly meritorious novel human islet research projects:

Type Name Institution Study Title Approval Date Completion Date
PilotMidhat H. AbdulredaUniversity of MiamiImmune Cell Dynamics During Destruction of Human Pancreatic Islets3/11/1112/31/12
PilotMelissa BrownPVLSI/UMass-Amherst/Role of TGF Beta Ligand Superfamily in Regulation of Human Islets2/15/1112/31/13
PilotAlejandro CaicedoUniversity of MiamiThe Role of Innervation for Hormone Secretion in Human Islets3/11/112/29/12
PilotShuibing ChenWeill Medical College of Cornell UniversityDeriving Functional Human Islets Using Chemical and Biological Approaches8/1/1112/13/13
PilotDawn B. DavisUniversity of Wisconsin, MadisonMechanisms of Beta Cell Proliferation3/11/117/31/14
PilotPaul HarrisColumbia UniversityDopaminergic Regulation of GSIS in T2DM4/13/113/30/12
PilotRaimund HerzogYale University School of MedicineThe Role of GSAP in the Pathophysiology of Type 2 Diabetes Mellitus3/11/111/12/13
PilotYumi ImaiEastern Virginia Medical SchoolType 2 Diabetes and Local Immune Response in Human Islets2/16/114/30/12
PilotDavid A. JacobsonVanderbilt UniversityModulation of Glucose Homeostasis by Pancreatic Islet Two-Pore-Domain Potassium3/11/117/31/13
PilotAleksandar JeremicGeorge Washington UniversityMolecular Determinants of Amylin Trafficking and Toxicity in Human Islets3/11/116/30/14
PilotAleksey V. MatveyenkoUniversity of California, Los AngelesThe Role of Melatonin Receptor Signaling in Regulation of Beta-Cell Survival and Function in Type 2 Diabetes2/15/1112/30/12
PilotShow-Ling ShyngOregon Health & Science UniversityPharmacological Chaperones of B-cell KATP Channels7/14/116/30/14
PilotRoland TischUniversity of North Carolina at Chapel HillGenetic Modification of Human Beta Cells12/12/1112/31/12
PilotKalpana VelmuruganDenver VA Medical CenterTargeting Phosphodiesterases in Beta Cells2/16/1112/31/13
PilotChristopher FrakerDiabetes Research InstituteNovel cytoprotective polymer formulations for islet cell encapsulation.8/13/128/31/14
PilotA. Osama GaberMethodist Hospital Research InstituteBioMEMS for Pancreatic Islet Revascularization for Transplantation5/8/1212/31/16
PilotEmma HeartMarine Biological LaboratoryAutomated Single Islets Metabolite Profiling via Non-Invasive Electrochemical Detection1/6/1212/31/14
PilotMalek El MuayedNorthwestern UniversityGene-Environment Interaction of ZnT8 and Cadmium - A Link to Diabetes Mellitus?1/30/1212/30/13
PilotYoko MullenBeckman Research Institute of the City of HopePilot Study to Test a New In Vitro Environment to Protect Human Islet Destruction Before and After Transplantation6/7/129/30/12
PilotJenna RickusPurdue UniversityBiosilicification of Pancreatic Islets for Treatment of Diabetes6/6/129/1/13
PilotYaron TomerMount Sinai School of MedicineCytokine Effects on Human Islets2/9/123/31/14
PilotNicholas ZavazavaUniversity of IowaSTEM CELL-DERIVED INSUIN PRODUCING CELLS CORRECT HYPERGLYCEMIA IN DIABETIC MICE11/21/1210/30/15
PilotJan CzyzykUniversity of Rochester Medical CenterThe role of anti-serpin antibodies in human islet transplant survival 12/2/136/30/16
PilotWeijun ShenCalibrIn vivo ß cell proliferation via targeted delivery of Gsk3b inhibitors10/9/139/1/15
PilotMark UngrinUniversity of CalgaryOptimizing islet survival and function12/19/1310/31/19
PilotChad S. HunterUniversity of Alabama at Birmingham (UAB)Transcriptional Complexes in Pancreatic Islet Function10/6/1412/31/19
PilotEynav KlechevskyWashington Univeristy in St. LouisAntigen presentation in T1D12/2/148/24/20
PilotMitchell KnutsonUniversity of FloridaMolecular mechanisms of iron uptake by pancreatic beta cells and their contribution to the development of diabetes7/17/1412/31/15
PilotXuelin LouMedical College of WisconsinInsulin granule trafficking in pancreatic beta cells4/9/1410/10/16
PilotDavid L. MorrisIndiana UniversityCharacterization of islet-associated macrophages and neutrophils in diabetes8/27/146/30/17
PilotRoberto GaetaniUniversity of California, San DiegoEvaluation of human islets extracellular matrix components for tissue engineering applications.12/11/156/30/18
PilotSenta K. GeorgiaChildren's Hospital Los AngelesDeveloping a personalized approach to beta cell replacement for a patient with a genetic form of diabetes10/16/1512/31/18
PilotLiora KatzMount Sinai School of MedicineT3 and glucose signaling in ß-cells and their effect on ChREBP mediated proliferation7/27/156/30/18
PilotSudhakar MuthyalaEmory UniversityEffect of hypoxia and human cytokines on free versus encapsulated human islets11/30/1511/15/16
PilotMichael RudnickiOttawa Hospital Research InstituteInduction of Pancreas Regeneration by Periostin7/15/156/30/17
PilotGaetano SantulliColumbia UniversityTargeting intracellular calcium leak as novel therapy for diabetes6/16/1511/30/17
PilotEmily SimsIndiana University School of MedicineBeta Cell Derived miR-21 as an Intrinsic Protective Response and Biomarker in Type 1 Diabetes7/29/1512/31/16
PilotMarika BogdaniBenaroya Research InstituteThe determination of the molecular size of hyaluronan in human islets. 7/27/1612/31/18
PilotGregory H. HockermanPurdue UniversityL-type Ca2+ channels in Beta Cell Dysfunction3/15/166/30/17
PilotRejji KuruvillaJohns Hopkins UniversityNeurotrophins as new regulators of islet biology4/13/167/4/16
PilotHui LiUniversity of VirginiaChiemerci fusion RNAs in pancreas islet cells and association with disease3/17/1612/31/19
PilotSasanka RamanadhamUniversity of AlabamaRole of lipid-signaling in beta-cell apoptosis3/1/1610/31/16
PilotSantiago A. Rodriguez-SeguiInstitute of Physiology, Molecular Biology and Neurosciences (IFIBYNE)INGAP and the control of beta cell mass and function: transcriptional and epigenomic effects3/15/164/1/19
PilotErik ShapiroMichigan State UniversityMRI of Islet Transplant5/25/1612/31/16
PilotSherry Voytik-HarbinPurdue UniversityEngineering an Islet Bioinstructive Microenvironment for Improved Survival, Function, Protection, and Delivery1/13/1612/31/17
PilotFlorence AnquetilLa Jolla InstitutePathophysiological role of IDO1 in beta cells and impact of its impairment in type 1 diabetes4/18/1711/1/18
PilotHolger A. RussBarbara Davis Center UC DenverIdentifying neo-antigens and investigating their formation in human beta cells3/13/172/28/19
PilotNatalia TamarinaUniversity of ChicagoGrowth Hormone-Releasing Hormone mediated effects on insulin secretion.3/13/1712/31/17