2010 (62)
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Balamurugan AN, Breite AG, Anazawa T, Loganathan G, Wilhelm
JJ, Papas KK, Dwulet FE, Francis E, McCarthy RC, Hering BJ: Successful human islet
islolation and transplantation indicating the importance of class 1 collagenase
and collagen degradation activity assay. Transplantation Vol 89 Issue 8 pp 954-961
2010 Apr 27
[PubMed Abstract]
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Bhandare R, Schug J, Le Lay J, et al. Genome-wide analysis
of histone modifications in human pancreatic islets. Genome Res. Apr;20(4):428-433.
[PubMed Abstract]
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Brehm MA, Bortell R, Diiorio P, Leif J, Laning J, Cuthbert
A, Yang C, Herlihy M, Burzenski L, Gott B, Foreman O, Powers AC, Greiner DL, Shultz
LD. Human immune system development and rejection of human islet allografts in spontaneously
diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice. Diabetes 2010;59(9):2265-70.
[PubMed Abstract]
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Chepurny OG, Kelley GG, Dzhura I, et al. PKA-dependent potentiation
of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM
in human islets of Langerhans. Am J Physiol Endocrinol Metab. Mar;298(3):E622-633.
[PubMed Abstract]
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Davis DB, Lavine JA, Suhonen JI, Krautkramer KA, Rabaglia
ME, Sperger JM, Fernandez LA, Yandell BS, Keller MP, Wang IM, Schadt EE, Attie AD.
FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation. Mol Endocrinol
2010;24(9):1822-34.
[PubMed Abstract]
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Faleck DM, Ali K, Roat R, Graham MJ, Crooke RM, Battisti
R, Garcia E, Ahima RS, Imai Y. Adipose differentiation-related protein regulates
lipids and insulin in pancreatic islets. Am J Physiol Endocrinol Metab 2010;299(2):E249-57.
[PubMed Abstract]
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Fiaschi-Taesch NM, Salim F, Kleinberger J, Troxell R, Cozar-Castellano
I, Selk K, Cherok E, Takane KK, Scott DK, Stewart AF. Induction of human beta-cell
proliferation and engraftment using a single G1/S regulatory molecule, cdk6. Diabetes
2010;59(8):1926-36.
[PubMed Abstract]
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Fomina-Yadlin D, Kubicek S, Walpita D, Dancik V, Hecksher-Sorensen
J, Bittker JA, Sharifnia T, Shamji A, Clemons PA, Wagner BK, Schreiber SL. Small-molecule
inducers of insulin expression in pancreatic alpha-cells. Proc Natl Acad Sci U S
A 2010;107(34):15099-104.
[PubMed Abstract]
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Fotino C, Ricordi C, Lauriola V, Alejandro R, Pileggi A.
Bone marrow-derived stem cell transplantation for the treatment of insulin-dependent
diabetes. Rev Diabet Stud 2010;7(2):144-57.
[PubMed Abstract]
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Fornoni A, Jeon J, Varona Santos J, et al. Nephrin is expressed
on the surface of insulin vesicles and facilitates glucose-stimulated insulin release.
Diabetes. Jan;59(1):190-199.
[PubMed Abstract]
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Fu Z, Zhang W, Zhen W, et al. Genistein induces pancreatic
beta-cell proliferation through activation of multiple signaling pathways and prevents
insulin-deficient diabetes in mice. Endocrinology. Jul;151(7):3026-3037.
[PubMed Abstract]
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Gonzalez-Pertusa JA, Dube J, Valle SR, et al. Novel proapoptotic
effect of hepatocyte growth factor: synergy with palmitate to cause pancreatic {beta}-cell
apoptosis. Endocrinology. Apr;151(4):1487-1498.
[PubMed Abstract]
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Guthalu Kondegowda N, Joshi-Gokhale S, Harb G, Williams
K, Zhang XY, Takane KK, Zhang P, Scott DK, Stewart AF, Garcia-Ocana A, Vasavada
RC. Parathyroid hormone-related protein enhances human ss-cell proliferation and
function with associated induction of cyclin-dependent kinase 2 and cyclin E expression.
Diabetes 2010;59(12):3131-8.
[PubMed Abstract]
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Heyduk E, Moxley MM, Salvatori A, Corbett JA, Heyduk T.
Homogeneous insulin and C-Peptide sensors for rapid assessment of insulin and C-peptide
secretion by the islets. Diabetes 2010;59(10):2360-5.
[PubMed Abstract]
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Huang CJ, Gurlo T, Haataja L, et al. Calcium-activated calpain-2
is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes. J Biol
Chem. Jan 1;285(1):339-348.
[PubMed Abstract]
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Huising MO, van der Meulen T, Vaughan JM, Matsumoto M, Donaldson
CJ, Park H, Billestrup N, Vale WW: CRFR1 is expressed on pancreatic beta cells,
promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent
manner. PNAS 2010 Jan 12; 912-917, Vol. 107, No. 2
[PubMed Abstract]
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Humphrey RK, Newcomb CJ, Yu SM, Hao E, Yu D, Krajewski S,
Du K, Jhala US. Mixed lineage kinase-3 stabilizes and functionally cooperates with
TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic
beta cells. J Biol Chem 2010;285(29):22426-36.
[PubMed Abstract]
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Humphrey RK, Yu SM, Flores LE, Jhala US. Glucose regulates
steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases.
J Biol Chem 2010;285(5):3406-16.
[PubMed Abstract]
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Jacques-Silva MC, Correa-Medina M, Cabrera O, Rodriguez-Diaz
R, Makeeva N, Fachado A, Diez J, Berman DM, Kenyon NS, Ricordi C, Pileggi A, Molano
RD, Berggren PO, Caicedo A. ATP-gated P2X3 receptors constitute a positive autocrine
signal for insulin release in the human pancreatic beta cell. Proc Natl Acad Sci
U S A 2010;107(14):6465-70.
[PubMed Abstract]
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Kaddis JS, Danobeitia JS, Niland JC, Stiller T, Fernandez LA.Am J Multicenter analysis
of novel and established variables associated with successful human islet isolation
outcomes. Transplant. 2010 Mar;10(3):646-56. doi: 10.1111/j.1600-6143.2009.02962.x.
Epub 2010 Jan 5.PMID: 20055802
[PubMed Abstract]
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Kennedy J, Katsuta H, Jung M-H, Marselli L, Goldfine AB,
Balis UJ, Sgroi D, Bonner-Weir S, Weir GC. Protective Unfolded Protein Response
in Human Pancreatic Beta Cells Transplanted into Mice. PLoS ONE;5(6):e11211.
[PubMed Abstract]
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Kim BJ, Zhou J, Martin B, Carlson OD, Maudsley S, Greig
NH, Mattson MP, Ladenheim EE, Wustner J, Turner A, Sadeghi H, Egan JM. Transferrin
fusion technology: a novel approach to prolonging biological half-life of insulinotropic
peptides. J Pharmacol Exp Ther 2010;334(3):682-92.
[PubMed Abstract]
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Kiselyuk A, Farber-Katz S, Cohen T, Lee S-H, Geron I, Azimi
B, Heynen-Genel S, Singer O, Price J, Mercola M, Itkin-Ansari P, Levine F: Phenothiazine
neuroleptics signal to the human insulin promoter as revealed by a novel high-throughput
screen. J Biomol Screen 15(6); 2010 Published online Jun 14, 2010
[PubMed Abstract]
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Kissler HJ, Niland JC, Olack B, et al. Validation of methodologies
for quantifying isolated human islets: an Islet Cell Resources study. Clin Transplant.
Mar 1;24(2):236-242.
[PubMed Abstract]
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Lee SH, Itkin-Ansari P, Levine F. CENP-A, a protein required
for chromosome segregation in mitosis, declines with age in islet but not exocrine
cells. Aging. 2010;2(11):785-790.
[PubMed Abstract]
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Leech CA, Dzhura I, Chepurny OG, Schwede F, Genieser HG,
Holz GG. Facilitation of ss-cell K(ATP) channel sulfonylurea sensitivity by a cAMP
analog selective for the cAMP-regulated guanine nucleotide exchange factor Epac.
Islets 2010;2(2):72-81.
[PubMed Abstract]
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Leibiger IB, Brismar K, Berggren PO: Novel aspects on pancreatic
beta-cell signal-transduction. Biochemical and Biophysical Research Communications
396 (2010) 111-115
[PubMed Abstract]
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Leitao CB, Bernetti K, Tharavanij T, et al. Lipotoxicity
and decreased islet graft survival. Diabetes Care. Mar;33(3):658-660.
[PubMed Abstract]
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Leitao CB, Froud T, Cure P, Tharavanij T, Pileggi A, Ricordi
C, Alejandro R. Nonalbumin proteinuria in islet transplant recipients. Cell Transplant
2010;19(1):119-25.
[PubMed Abstract]
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Leoni L, Serai SD, Haque ME, Magin RL, Roman BB. Functional
MRI characterization of isolated human islet activation. NMR Biomed 2010;23(10):1158-65.
[PubMed Abstract]
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Leoni L, Roman BB. MR imaging of pancreatic islets: tracking
isolation, transplantation and function. Curr Pharm Des. May 2010;16(14):1582-1594.
[PubMed Abstract]
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Liew CW, Bochenski J, Kawamori D, et al. The pseudokinase
tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis
in human and mouse beta cells. J Clin Invest. Aug 2 2010;120(8):2876-2888.
[PubMed Abstract]
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Liu S, Navarro G, Mauvais-Jarvis F. Androgen excess produces
systemic oxidative stress and predisposes to beta-cell failure in female mice. PLoS
One 2010;5(6):e11302.
[PubMed Abstract]
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Loganathan G, Dawra RK, Pugazhenthi S, Wiseman AC, Sanders
MA, Saluja AK, Sutherland DE, Hering BJ, Balamurugan AN. Culture of impure human
islet fractions in the presence of alpha-1 antitrypsin prevents insulin cleavage
and improves islet recovery. Transplant Proc 2010;42(6):2055-7.
[PubMed Abstract]
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Mita A, Ricordi C, Messinger S, Miki A, Misawa R, Barker
S, Molano RD, Haertter R, Khan A, Miyagawa S, Pileggi A, Inverardi L, Alejandro
R, Hering BJ, Ichii H. Antiproinflammatory effects of iodixanol (OptiPrep)-based
density gradient purification on human islet preparations. Cell Transplant 2010;19(12):1537-46.
[PubMed Abstract]
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Mondal AK, Das SK, Baldini G, et al. Genotype and tissue-specific
effects on alternative splicing of the transcription factor 7-like 2 gene in humans.
J Clin Endocrinol Metab. Mar;95(3):1450-1457.
[PubMed Abstract]
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Nduaguibe CC, Bentsi-Barnes K, Mullen Y, Kandeel F, Al-Abdullah
I. Serine protease inhibitors suppress pancreatic endogenous proteases and modulate
bacterial neutral proteases. Islets 2010;2(3):200-6.
[PubMed Abstract]
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Niland JC, Stiller T, Cravens J, Sowinski J, Kaddis J, Qian
D 2010 Effectiveness of a web-based automated cell distribution system. Cell Transplant
19:1133-1142
[PubMed Abstract]
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Ogihara T, Chuang JC, Vestermark GL, et al. Liver X receptor
agonists augment human islet function through activation of anaplerotic pathways
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[PubMed Abstract]
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Omori K, Mitsuhashi M, Todorov I, et al. Microassay for
glucose-induced preproinsulin mRNA expression to assess islet functional potency
for islet transplantation. Transplantation. Jan 27 2010;89(2):146-154.
[PubMed Abstract]
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Omori K, Todorov I, Shintaku J, et al. P38alpha-selective
mitogen-activated protein kinase inhibitor for improvement of cultured human islet
recovery. Pancreas. May;39(4):436-443.
[PubMed Abstract]
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Ortqvist E, Brooks-Worrell B, Lynch K, Radtke J, Bekris
LM, Kockum I, Agardh CD, Cilio CM, Lethagen AL, Persson B, Lernmark A, Reichow J,
Oak S, Palmer JP, Hampe CS. Changes in GAD65Ab-specific antiidiotypic antibody levels
correlate with changes in C-peptide levels and progression to islet cell autoimmunity.
J Clin Endocrinol Metab 2010;95(11):E310-8.
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Papas KK, Colton CK, Qipo A, Wu H, Nelson RA, Hering BJ,
Weir GC, Koulmanda M. J Prediction of marginal mass required for successful islet
transplantation. Invest Surg. 2010 Feb;23(1):28-34.
[PubMed Abstract]
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Pisania A, Weir GC, O'Neil JJ, Omer A, Tchipashvili V, Lei
J, Colton CK, Bonner-Weir S. Quantitative analysis of cell composition and purity
of human pancreatic islet preparations. Lab Invest 2010;90(11):1661-75.
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Pisania A, Papas KK, Powers DE, Rappel MJ, Omer A, Bonner-Weir
S, Weir GC, Colton CK. Enumeration of islets by nuclei counting and light microscopic
analysis. Lab Invest 2010;90(11):1676-86.
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Potter KJ, Abedini A, Marek P, et al. Islet amyloid deposition
limits the viability of human islet grafts but not porcine islet grafts. Proc Natl
Acad Sci U S A. Mar 2;107(9):4305-4310.
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Pugazhenthi U, Velmurugan K, Tran A, Mahaffey G, Pugazhenthi
S: Anti-inflammatory action of exendin-4 in human islets is enhanced by phosphodiesterase
inhibitors: potential therapeutic benefits in diabetic patients. Diabetologia Published
online: 16July 2010
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Rink JS, McMahon KM, Chen X, Mirkin CA, Thaxton CS, Kaufman
DB. Transfection of pancreatic islets using polyvalent DNA-functionalized gold nanoparticles.
Surgery. Aug;148(2):335-345.
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Ritzel, R. A.; Jayasinghe, S.; Hansen, J. B.; Sturis, J.;
Langen, R.; Butler, P. C. Beta-cell selective K(ATP)-channel activation protects
beta-cells and human islets from human islet amyloid polypeptide induced toxicity.
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Rohatgi N, Remedi MS, Kwon G, Pappan KL, Marshall CA, McDaniel
ML. Therapeutic strategies to increase human β-cell growth and proliferation by
regulating mTOR and GSK-3/β-catenin pathways. The Open Endocrinology Journal, 2010,
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Scott WE, 3rd, O'Brien TD, Ferrer-Fabrega J, Avgoustiniatos
ES, Weegman BP, Anazawa T, Matsumoto S, Kirchner VA, Rizzari MD, Murtaugh MP, Suszynski
TM, Aasheim T, Kidder LS, Hammer BE, Stone SG, Tempelman LA, Sutherland DE, Hering
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Scott WE, 3rd, Weegman BP, Ferrer-Fabrega J, Stein SA, Anazawa
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Soleimanpour SA, Crutchlow MF, Ferrari AM, Raum JC, Groff
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Stitzel ML, Sethupathy P, Pearson DS, Chines PS, Song L,
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Todorov I, Nair I, Avakian-Mansoorian A, Rawson J, Omori
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Tsunekawa S, Demozay D, Briaud I, McCuaig J, Accili D, Stein
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Vendrame F, Pileggi A, Laughlin E, et al. Recurrence of
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Wang Z, Thurmond DC. Differential phosphorylation of RhoGDI
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Wu H, Panakanti R, Li F, Mahato RI 2010 XIAP gene expression
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Yamamoto T, Mita A, Ricordi C, et al. Prolactin supplementation
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Zhang Z, Liew CW, Handy DE, et al. High glucose inhibits
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Zhao J, Schug J, Li M, Kaestner KH, Grant SFA: Disease-associated
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